Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
نویسندگان
چکیده
منابع مشابه
Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
Lifespan can be extended by reduction of dietary intake. This practice is referred to as dietary restriction (DR), and extension of lifespan by DR is evolutionarily conserved in taxonomically diverse organisms including yeast, invertebrates, and mammals. Although these two often-stated facts carry the implication that the mechanisms of DR are also evolutionarily conserved, extension of lifespan...
متن کاملDietary restriction in rodents--delayed or retarded ageing?
Dietary restriction (DR) feeding increases survival significantly in strains of rats and mice. There remains however, the question as to whether these two species are always responding in an identical manner to the feeding regime. Enhanced survival can be achieved either through a set-point effect, where there is a change in the elevation of the Ln age-specific mortality rate or, by a decrease ...
متن کاملDietary Restriction and Nutrient Balance in Aging
Dietary regimens that favour reduced calorie intake delay aging and age-associated diseases. New evidences revealed that nutritional balance of dietary components without food restriction increases lifespan. Particular nutrients as several nitrogen sources, proteins, amino acid, and ammonium are implicated in life and healthspan regulation in different model organisms from yeast to mammals. Agi...
متن کاملOptimization of dietary restriction protocols in Drosophila.
Dietary restriction (DR) extends life span in many organisms, through unknown mechanisms that may or may not be evolutionarily conserved. Because different laboratories use different diets and techniques for implementing DR, the outcomes may not be strictly comparable. This complicates intra- and interspecific comparisons of the mechanisms of DR and is therefore central to the use of model orga...
متن کاملTreating aging: progress toward dietary restriction mimetics
During the last decade, biogerontologists have labored to understand the biological basis of the aging process by studying the genes and signaling pathways that regulate it. But the last year has seen a breakthrough in a different direction: toward treatments that might slow aging by mimicking the effects of dietary restriction.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2007
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.0030057